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Genome Guardian

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Steam Page
Developer
Alpherior
Publisher
Alpherior
Release
May 7, 2024
2 years and 86 days ago
Steam Reviews
Very Positive782 reviews91.8%

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Latest Contributor: IGF TeamEdit notes
Updated: Jul 16, 2026Developer scaleThe operating scale of the game's developer.
Updated: Jul 16, 2026Publisher scaleThe operating scale of the game's publisher.
Updated: Jul 16, 2026Publisher statusHow the game's publishing relationship is classified.
Search Google: How is Genome Guardian and Alpherior funded?FundingThe known source of funding behind the game.
Search Google: Who controls the creative direction and IP for Genome Guardian and Alpherior?Creative controlWho appears to retain creative control of the game.
Updated: Jul 16, 2026Release statusWhether and how the game has been released.

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About the Game

Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".

Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!

  • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!

  • Bomb + Bomb doubles down on explosive power to make Bazooka!

  • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

  • 49 Turrets with unique strengths and functions

  • 96 Perks to mix and match that drastically change how you play

  • 75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs

  • 64 Mutations alter the challenges you face each run

  • 20-minute Runs that can be continued in Endless Mode

  • 75 Bassy Electronic Tunes that adapt to the current mood & intensity

  • Cosmetics like spider legs and tank tread

  • Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!

  • 100 Steam Achievements

  • Steam Trading Cards

  • Cloud Save

  • Plays great on Steam Deck!!!

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